Print this Page


Journal Articles


83 [83] C Mou, F Ali, A Malaviya, C J Bettinger. Electrochemical-mediated gelation of catechol-bearing hydrogels based on multimodal crosslinking. Journal of Materials Chemistry B 2019. (in press).
82 [82] C J Bettinger. Edible hybrid microbial-electronic sensors for bleeding detection and beyond. Hepatobiliary Surgery and Nutrition 2019. (in press).
81 [81] I S Kwon, C J Bettinger. Polydopamine Nanostructures as Biomaterials for Medical Applications. Journal of Materials Chemistry B 2018. 6 6895-6903.
80 [80] C J Bettinger. Advanced Materials for Ingestible Electromechanical Medical Devices. Angewandte Chemie 2018. 57 (52) 16946-16958.
79 [79] Z Ding, F Fatollahi-Fard, I S Kwon, P C Pistorius, C J Bettinger. Polydopamine Nanomembranes as Adhesion Layers for Improved Corrosion Resistance in Low Carbon Steel. Advanced Engineering Materials 2018. 20 (11) 1800621.
TOC_20180404 [78] P-J Chiang, G Tang, I S Kwon, S Eristoff, C J Bettinger. Reversible Chemo-Topographic Control of Adhesion in Polydopamine Nanomembranes. Macromolecular Materials and Engineering 2018. 303 (11) 1800258.
77 [77] K Ye, D Kaplan, G Bao, C J Bettinger, G Forgacs, C Dong, A Khademhosseini, Y Ke, K Leong, A Sambanis, W Sun, P Yin. Advanced Cell and Tissue Biomanufacturing. ACS Biomaterials Science & Engineering 2018. 4 (7) 2292–2307.
76 [76] W-C Huang, X C Ong, I S Kwon, C Gopinath, H Wu, G K Fedder, R Gaunt*, C J Bettinger*. Ultra-Compliant Hydrogel-Based Neural Interfaces Fabricated by Aqueous-Phase Microtransfer Printing. Advanced Functional Materials 2018. 28 (29) 1801059.
75 [75] C J Bettinger. Recent Advances in Materials and Flexible Electronics for Peripheral Nerve Interfaces. Bioelectronic Medicine 2018. 4 (1) DOI: 10.1186/s42234-018-0007-6.
74 [74] I Kwon, G Tang, P-J Chiang, C J Bettinger. Texture-dependent Adhesion in Polydopamine Nanomembranes. ACS Applied Materials and Interfaces 2018. 10 (9) 7681–7687.
73 [73] X Tang, C J Bettinger. Multimodal Underwater Adhesion Using Self-assembled Dopa-bearing ABA Triblock Copolymer Networks. Journal of Materials Chemistry B 2018. 6 545–549.
72 [72] A Lampel, S McPhee, H-A Park, G G Scott, S Humagain, D R Hekstra, B Yoo, P W J M Frederix, T D Li, R R Abzalimov, S G Greenbaum, T Tuttle, C Hu, C J Bettinger, R V Ulijn. Polymeric peptide pigments with sequence-encoded properties. Science 2017. 356 (6342) 1064–1068.
71 [71] L Klosterman, Z Ahmad, V Viswanathan, C J Bettinger. Synthesis and Measurement of Cohesive Mechanics in Polydopamine Nanomembranes. Advanced Materials Interfaces 2017. 4 (10) 1700041.
70 [70] W-C Huang, F Ali, J Zhao, K Rhee, C Mou, C J Bettinger. Ultrasound-Mediated Self-Healing Hydrogels Based on Tunable Metal-Organic Bonding. Biomacromolecules 2017. 18 (4) 1162–1171.
69 [69] L Klosterman, C J Bettinger. Calcium-Mediated Control of Polydopamine Film Oxidation and Iron Chelation. International Journal of Molecular Sciences 2017 18 (1) 14.
68-mod [68] H Ding, Z Wang, G Xie, C Mahoney, Rachel Ferebee, M Zhong, W F M Daniel, J Pietrasik, S S Sheiko, C J Bettinger, M R Bockstaller, K Matyjaszewski. Preparation of Well-defined ZnO Nanoparticle Hybrid Materials. Polymer 2016 107 492–502.
67 [67] H Ding, S Park, M Zhong, X Pan, J Pietrasik, C J Bettinger, K Matyjaszewski. Facile Arm-First Synthesis of Star Block Copolymers via ARGET ATRP with ppm Amounts of Catalyst. Macromolecules 2016 49 (18) 6752–6760.
66 [66] H Wu, V Sariola, J Zhao⊥, H Ding, M Sitti, C J Bettinger. Composition-dependent Underwater Adhesion of Catechol-Bearing Hydrogels. Polymer International 2016 65 (11) 1355–1359.
65 [65] P Pholpabu, S S Yerneni, C Zhu, P G Campbell, C J Bettinger. Controlled Release of Small Molecules from Elastomers for Reducing Epidermal Downgrowth in Percutaneous Devices. ACS Biomaterials Science and Engineering 2016. 2 (9) 1464–1470.
FIG-PI [64] H-A Park, Y J Kim, I S Kwon, L Klosterman, C J Bettinger. Lithium purification from aqueous solutions using bioinspired redox active melanin membranes. Polymer International 2016 65 (11) 1331–1338.
63 [63] J Epstein, Wee-Liat Ong, C J Bettinger, J A Malen. Temperature Dependent Thermal Conductivity and Thermal Interface Resistance of Pentacene Thin Films with Varying Morphology. ACS Applied Materials and Interfaces 2016. 8 (29) 19168–19174.
TOCfigure [62] H Ding, M Zhong, H Wu, S Park, J W Mohin, L Klosterman, Z Yang, H Yang, K Matyjaszewski, C J Bettinger. Elastomeric Conducting Polyaniline Formed Through Topological Control of Molecular Templates. ACS Nano 2016. 10 (6) 5991–5998.
Print [61] I Kwon, Y J Kim, L Klosterman, M Forssell, G K Fedder, C J Bettinger. In vitro electrochemical characterization of polydopamine melanin as a tissue stimulating electrode material. Journal of Materials Chemistry B 2016. 4 3031-3036.


Print [60] Y J Kim, A Khetan, W Wu, S E Chun, V Viswanathan, J F Whitacre, C J Bettinger. Evidence of Porphyrin-like Structures in Natural Melanin Pigments Using Electrochemical Fingerprinting. Advanced Materials 2016. 28 (16) 3173–3180.
59 [59] C J Bettinger. Materials Advances for Next-Generation Ingestible Electronic Devices. Trends in Biotechnology 2015. 33 575–585.
58 [58] C J Bettinger and N Stingelin. Journal of Materials Chemistry B & C joint themed issue: organic bioelectronics. Journal of Materials Chemistry B & C 2015. 3 6405–6406.
57 [57] C Ninh, A Iftikhar, M Cramer, C J Bettinger. Diffusion–reaction models of genipin incorporation into fibrin networks. Journal of Materials Chemistry B 2015. 3 4607-4615.
56 [56] H Wu, V Sariola, C Zhu, J Zhao, M Sitti, C J Bettinger. Transfer Printing of Metallic Microstructures on Adhesion-Promoting Hydrogel Substrates. Advanced Materials 2015. 27 (22) 3398–3404.
55 [55] A Balasubramanian and C J Bettinger. Shape Recovery Kinetics in Vascularized 3D Printed Polymeric Actuators. Advanced Engineering Materials 2015. 31 (11) 3451–3458.
54 [54] L Klosterman, J K Riley, C J Bettinger. Control of Heterogeneous Nucleation and Growth Kinetics of Dopamine-Melanin by Altering Substrate Chemistry. Langmuir 2015. 31 (11) 3451–3458.
53 [53] S Savagatrup, A D Printz, H Wu, K M Rajan, E J Sawyer, A V Zaretski, C J Bettinger, D J Lipomi. Viability of Stretchable Poly(3-heptylthiophene) (P3HpT) for Organic Solar Cells and Field-effect Transistors. Synthetic Metals 2015. 203 208-214.
52 [52] C Zhu and C J Bettinger. Photoreconfigurable Physically Cross-Linked Triblock Copolymer Hydrogels: Photodisintegration Kinetics and Structure–Property Relationships. Macromolecules 2015. 48 (5) 1563–1572.
51 [51] P Pholpabu, P Pholpabu, S Kustra, H Wu, A Balasubramanian, C J Bettinger. Lithography-Free Fabrication of Reconfigurable Substrate Topography for Contact Guidance. Biomaterials 2015. 39 164–172.
bm-2014-00990z-TOC.jpg [50] C Zhu, S Ninh, C J Bettinger. Photoreconfigurable Polymers for Biomedical Applications: Chemistry and Macromolecular Engineering. Biomacromolecules 2014. 15 (10) 3474–3494.


[49] H Wu, M Menon, C Zhu, A Balasubramanian, C J Bettinger. Lithography-Free Microfabrication of Electrode Arrays with 2 um Electrode Gaps Using Topographic Templates. Advanced Materials Interfaces 2014. 1 (9) 1400301.
48-ver2 [48] Y J Kim, W Wu, S E Chun, J Whitacre*, C J Bettinger*. Catechol-mediated Cycling Stability in Secondary Mg Batteries Using Eumelanin Cathodes. Advanced Materials 2014. 26 (38) 6572-6579.


[47] H Ding, M Zhong, Y J Kim, P Pholpabu, A Balasubramanian, C M Hui, H He, H Yang*, K Matyjaszewski*, C J Bettinger*. Biologically Derived Soft Conducting Hydrogels Using Heparin-Doped Polymer Networks. ACS Nano 2014. 8 (5) 4348-4357.


[46] A Balasubramanian, M R Standish, C J Bettinger. Microfluidic Phase-Change Materials for Rapid Control of Macroscopic Stiffness. Advanced Functional Materials 2014. 24 (30) 4860-4866.


[45] C Ninh, M Cramer, C J Bettinger. Photoresponsive Hydrogel Networks using Melanin Nanoparticle Photothermal Sensitizers. Biomaterials Science 2014. 2 (5) 766-774.

[44] C Zhu and C J Bettinger. Light-Induced Remodeling of Physically Crosslinked Hydrogels Using Near-IR Wavelengths. Journal of Materials Chemistry B 2014. 2 (12) 1613 – 1618.

[43] Y J Kim, W Wu, S-E Chun, J Whitacre*, C J Bettinger*. Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices. Proceedings of the National Academy of Sciences USA 2013. 110 (5) 20912–20917.
TOC Figure

[42] H Wu, M Menon, E Gates, A Balasubramanian, C J Bettinger. Reconfigurable Topography for Rapid Solution Processing of Transparent Conductors. Advanced Materials 2013. 26 (5) 706-711.

[41] C Ninh and C J Bettinger. Reconfigurable Biodegradable Shape-Memory Elastomers via Diels-Alder Coupling. Biomacromolecules 2013. 14 (7) 2162-2170.

[40] C Zhu and C J Bettinger. Light-Induced Disintegration of Robust Physically Crosslinked Polymer Networks. Macromolecular Rapid Communications 2013. 34 (18) 1446-1451.

[39] Y J Kim, S-E Chun, J Whitacre, C J Bettinger. Self-Deployable Current Sources Fabricated from Edible Materials. Journal of Materials Chemistry B 2013. 1 3781-3788.

[38] H Wu, S Kustra, E Gates, C J Bettinger. Topographic Substrates as Strain Relief Features in Stretchable Organic Thin Film Transistors. Organic Electronics 2013. 14 (6) 1636-1642.

[37] A Balasubramanian, R Morhard, C J Bettinger. Shape-Memory Microfluidics. Advanced Functional Materials 2013. 23 (38) 4832–4839.

[36] C Zhu, S Kustra, C J Bettinger. Photocrosslinkable Biodegradable Elastomers Based on Cinnamate-Modified Polyesters. Acta Biomaterialia 2013. 9 (7) 7362–7370.

[35] P Meredith, C J Bettinger, M Irimia-Vladu, A B Mostert, P E Schwenn. Electronic and optoelectronic materials and devices inspired by nature. Review of Physics 2013. 76 034501.

[34] S Kustra and C J Bettinger. Smart polymers and interfaces for
dynamic cell-biomaterials interactions
. MRS Bulletin 2012. 37 (9) 836-846.

[33] S Kustra, H Wu, S Basu, G K Rohde, C J Bettinger. High Throughput Arrays for Rapid Characterization of Solution Processable Transparent Conducting Electrodes. Small 2012. 8 (24) 3746–3751.

[32] M Muskovich and C J Bettinger. (Invited Review) Biomaterials-Based Electronics: Polymers and Interfaces for Biology and Medicine. Advanced Healthcare Materials 2012. 1 (3) 248-266.

[31] C J Bettinger, J T Borenstein, A Khademhosseini. (Special Section) Nanostructured Materials for Tissue Regeneration. IEEE Transactions on Nanobioscience 2012. 11 (1). 1-61.


[30] H B Akkerman, A C Chang, E Verploegen, C J Bettinger, M F Toney, Z Bao. Fabrication of organic semiconductor crystalline films and crystals from solution by confined crystallization. Organic Electronics 2011. 13 (2). 235-243.

[29] D W Lin, C J Bettinger, J P Ferreia, C L Wang, Z Bao. A Cell-compatible Conductive Film from a Carbon Nanotube Network Adsorbed on Poly-L-Lysine. ACS Nano 2011. 5 (12) 10026–10032.

[28] A N Sokolov, B C-K Tee, C J Bettinger, J B-H Hok, Z Bao. Chemical and Engineering Approaches to Enable Organic Field-Effect Transistors for Electronic Skin Applications. Accounts of Chemical Research 45 (3) 361–371.
[27] C J Bettinger, H A Becerril, D H Kim, B-L Lee, S Lee, Z Bao. Microfluidic Arrays for Rapid Screening of Solution Processable Organic Semiconductors. Advanced Materials 2011. 23 (10) 1257-1261.
[26] C J Bettinger. (Invited Review). Biodegradable Elastomers for Tissue Engineering and Cell-Biomaterial Interactions. Macromolecular Bioscience 2011. 11 (4) 467-82.
[25] C J Bettinger. (Invited Review) Synthetic Biodegradable Elastomers for Drug Delivery and Tissue Engineering. Pure and Applied Chemistry 2011. 83 (1) 9-24.
[24] C J Bettinger, and J T Borenstein. (Invited Review) Biomaterials-based Microfluidics for Engineered Tissue Constructs. Soft Matter 2010. 6 (20) 4999-5015
23 [23] E Verploegen, R Mondal, C J Bettinger, M F Toney, Z Bao. Investigating the Effects of Thermal Annealing Upon the Morphology of Polymer-Fullerene Blends with In-situ Grazing Incidence X-ray Scattering. Advanced Functional Materials 2011. 20 (20) 3519-3529.
[22] C J Bettinger and Z Bao. Organic Thin Film Transistors Fabricated on Resorbable Biomaterial Substrates. Advanced Materials 2010. 22 (5) 651-655.
**Top 5 Downloaded Paper in Nov-09 in Advanced Materials.
**Selected feature in “Advances in Advance” and “MaterialsViews” sections of Advanced Materials.
**Featured in MIT Technology Review. “Biodegradable Transistors” Nov-09.
[21] C J Bettinger and Z Bao. (Invited Review) Biomaterials-Based Organic Electronic Devices. Polymer International 2010. 59 (5) 563-567.
[20] J P Bruggeman, C J Bettinger, R Langer. Biodegradable Xylitol-based Polymers: In Vivo Behavior and Biocompatibility. Journal of Biomedical Materials Research Part A 2010 95A (1) 92-104.
[19] I S Tobias, H Lee, G C Engelmayr Jr, C J Bettinger, D Macaya, M J Cima. Bioresorbable Elastomeric Osmotic Pump for the Controlled Delivery of Ciprofloxacin. Journal of Controlled Release 2010. 146 (3) 356-362.
[18] C J Bettinger. (Invited Review) Synthesis and Microfabrication of Biomaterials for Soft Tissue Engineering. Pure and Applied Chemistry 2009. 81 (12) 2183-2201.
[17] C J Bettinger, J P Bruggeman, A Misra, J T Borenstein, R Langer. Biocompatibility of Melanin Films for Potential Nerve Tissue Engineering Applications. Biomaterials 2009. 30 (17) 3050-3057.
[16] C J Bettinger, R Langer, J T Borenstein. (Review) Engineering Synthetic Substrate Micro- and Nanotopography to Control Cell Function. Angewandte Chemie 2009. 48 (30) 5406-5415.
[15] J P Bruggeman, B J de Bruin, C J Bettinger, R Langer. Biodegradable Poly(polyol sebacate) Polymers. Biomaterials 2008. 29 (36) 4726-4725.
[14] C J Bettinger, K M Kulig, J P Vacanti, J T Borenstein, R Langer. Nanofabricated Collagen-Inspired Synthetic Elastomers for Primary Hepatocyte Culture. Tissue Engineering Part A 2009. 15 (6) 1321-1329.
[13] C J Bettinger, J P Bruggeman, J T Borenstein, R Langer. In Vitro and In Vivo Degradation of Poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s. Journal of Biomedical Materials Research Part A 2008. 91A (4) 1077-1088.
[12] G C Engelmayr, M Cheng, C J Bettinger, J T Borenstein, R Langer, L E Freed. Accordion-Like Honeycombs for Tissue Engineering Cardiac Anisotropy. Nature Materials 2008. 7 (12) 1003-1010.
**Selected as Feature Cover.
**Feature in Scientific American. “Progress In Tissue” May-09.
**Featured in Faculty of 1000 Biology.
**Featured in Discover Magazine. “Researchers could grow replacement tissue to patch broken hearts.” Nov-08.
**Featured in MIT Technology Review. “Patching Hearts: An artificial scaffold helps engineered hearts.” Nov-08.
[11] A Mahdavi, L Ferreira, C Sundback, J W Nichol, E P Chan, D J D Carter, C J Bettinger, S Patanavanich, L Chignozha, E B Joseph, A Galakatos, H Pryor, I Pomerantseva, P Masiakos, W Faquin, A Zumbuehl, S Hong, J Borenstein, J Vacanti, R Langer, J M Karp. A Biodegradable and Biocompatible Gecko-Inspired Tissue Adhesive. Proceedings of the National Academy of Sciences USA 2008. 105 (7) 2307-2312.
**Selected as Feature Cover.
**Featured in Reuters News. “Team makes gecko-inspired adhesive bandage.” 18-Feb-08.
**Featured in Popular Mechanics. 18-Feb-08.
[10] J P Bruggeman, C J Bettinger, C L E Nijst, D S Kohane, R Langer. Biodegradable Xylitol-Based Polymers. Advanced Materials 2008. 20 (10) 1922-1927.
[9] C J Bettinger, J P Bruggeman, J T Borenstein, R Langer. Amino Alcohol-Based Degradable Poly(ester amide) Elastomers. Biomaterials 2008. 29 (15) 2315-2325.
[8] C J Bettinger, Z Zhang, S Gerecht, J Borenstein, R Langer . Enhancement of In Vitro Capillary Tube Formation by Substrate Nanotopography. Advanced Materials 2008. 20 (1) 99-103.
**Selected feature in “Advances in Advance” section of Advanced Materials.
**Featured in Scientific American. “Progress In Tissue” May 2009, 64-71.
**Featured in BBC News Online. “Artificial blood vessels ‘closer’.” 26-Dec-07.
[7] C L E Nijst, J P Bruggeman, J M Karp, L Ferreira, A Zumbuehl, C J Bettinger, Robert Langer. Synthesis and Characterization of Photocurable Elastomers from Poly(glycerol-co-sebacate). Biomacromolecules 2007. 8 (10) 3067-3073.
[6] C J Bettinger, K M Cyr, A Matsumoto, R Langer, J T Borenstein and D L Kaplan. Silk Fibroin Microfluidic Devices. Advanced Materials 2007. 19 (19) 2847-2850.
**Cited in New Scientist: C Biever. Breathing Life into Artificial Organs. New Scientist 2007. 2589 24-25.
[5] S Gerecht-Nir*, C J Bettinger*, Z Zhang, J Borenstein, G Vunjak-Novakovic, R Langer . The Effect of Actin-Disrupting Agents on Contact Guidance of Human Embryonic Stem Cells. Biomaterials 2007. 28 (28) 4068-4077.
[4] C J Bettinger, E Weinberg, K Kulig, J Vacanti, Y Wang, J T Borenstein, R Langer. Three-dimensional microfluidic tissue engineering scaffolds using a flexible biodegradable polymer. Advanced Materials 2006. 18 (2) 165-69.
**Featured in Scientific American. “Progress In Tissue” May 2009, 64-71.
**Cited in New Scientist: C Biever. Breathing Life into Artificial Organs. New Scientist 2007. 2589 24-25.
[3] C J Bettinger, B Orrick, A Misra, R Langer, J T Borenstein. Microfabrication of poly(glycerol-sebacate) for contact guidance applications. Biomaterials 2006. 27 (12) 2558-2565.
[2] A Khademhosseini, C J Bettinger, J Karp, Junji Fukuda, J Yeh, J Borenstein, R Langer. (Review) Interplay of biomaterials and micro-scale technologies for advancing biomedical applications. Journal of Biomaterials Science: Polymer Edition 2006. 17 (11) 1221-1240.
[1] K D Chapman, B Venables, R Markovic, R W Blair Jr, and C J Bettinger. N-Acylethanolamines in Seeds. Quantification of Molecular Species and Their Degradation upon Imbibition. Plant Physiology 1999. 120 (4) 1157–1164.

Books & Book Chapters

J T Borenstein, C J Bettinger, S Tao. (Textbook) Microfluidic Cell Culture Systems. Elsevier, Cambridge, MA, USA 2012.

C J Bettinger, J T Borenstein, R Langer, in Nanotechnology and Tissue Engineering: The Scaffold. Micro- and Nanofabrication of Biodegradable Materials for Tissue Engineering. (Eds: C T Laurencin, L S Nair), CRC Press, Boca Raton, FL, USA 2008.

C J Bettinger, J T Borenstein, R Langer, in Principles of Tissue Engineering, 3rd Edition. Micro- and Nanofabrication of Tissue Engineering Scaffolds. (Eds: R Lanza, R Langer, J Vacanti), Elsevier, Burlington, MA, USA. 2007.


J Wang, C J Bettinger, R Langer, J T Borenstein. Biodegradable Microfluidic Scaffolds for Tissue Engineering from Amino Alcohol-based Poly(ester amide) Elastomers. Organogenesis 2010. 6 (4) 212–216.

C J Bettinger, J Borenstein. Engineered Nanotopographic Structures for Applications in Tissue Engineering and Regenerative Medicine. IEEE/NIH Life Sciences and Applications Workshop. Bethesda, MD. Apr 2009.

C J Bettinger, Z Zhang, S Gerecht, J Borenstein, R Langer . Enhancement of In Vitro Capillary Tube Formation with Synthetic Nanotopography. NSTI Nanotechnology Conference. Boston, MA. Mar 2008.

C J Bettinger, S Gerect-Nir, Z Zhang, J T Borenestein, G Vunjak-Novakovic, R Langer. Nanopatterned Surfaces for Controlled Human Embryonic Stem Cell Differentiation. ASAIO Journal 2006. 52(2):8A.

J T Borenstein, C J Bettinger, D J Carter. Nanotopographic Tools for Vascular Tissue Engineering. In Vitro Cellular & Developmental Biology – Animal 2005. 41:10A.

C J Bettinger, J T Borenstein, R Langer. Biodegradable Microfluidic Scaffolds for Vascular Tissue Engineering. MRS Proceedings 2004. Symposium AA.

Permanent link to this article: